The Okur-Chung Neurodevelopmental Syndrome Mutation CK2K198R Leads to a Rewiring of Kinase Specificity
Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of protein kinase CK2.The most frequently occurring mutation is lysine 198 to arginine (K198R).To investigate the impact of this mutation, we first generated a high-resolution phosphorylation motif of CK2WT, includ